☆个人概况 

王亮，男，理学博士，教授，硕士生导师。

所属学科：应用化学  农药学

2011年在德国海德堡大学获得理学博士学位，有机化学专业。2012年3月~2013年2月在瑞士巴塞尔大学从事博士后研究工作。2014年12月至今在青岛农业大学任教授，主要开展有机合成、绿色化学、过渡金属催化以及药物分子设计等方面的研究。目前在Angew. Chem. Int. Ed., Org. Lett., J. Org. Chem., Org. Chem. Front., Adv. Synth. Catal.等国际期刊已发表SCI论文43篇, 在有机合成、生物医药等领域的工作得到国际社会的广泛认可。

☆联系方式

  手机：18561880316

  Email: liangwang0532#yeah.net

  工作单位：青岛农业大学28大神官方在线预测

  通讯地址：山东省青岛市城阳区长城路700号

  个人网页：

/liangwang/Website/default.html

☆研究领域

216. 过渡金属催化
216. 药物分子设计
216. 绿色化学
216. 有机合成

1.一作或通讯作者的文章

(1) Liang Wang，Jian Xiao，C(sp3)–H bond functionalization by sequential hydride transfer/cyclization: Electronic effect and steric effect controlled regioselectivity, Org. Chem. Front.，2016，3(5): 635~638

(2) Liang Wang, Jian Xiao, Advancement in Cascade [1,n]-Hydrogen Transfer/Cyclization: A Method for Direct Functionalization of Inactive C(sp3)-H Bonds，Adv. Syn. Catal., 2014, 356(6): 1137~1171

(3) Liang Wang，Yuye Chen, Jian Xiao，Alkylideneindoleninium Ions and Alkylideneindolenines: Key Intermediates for the Asymmetric Synthesis of 3-Indolyl Derivatives，Asian J. Org. Chem., 2014, 3(10): 1036~1052

(4) Liang Wang, Jian Xiao, Teck-Peng Loh, Organocatalytic β-Functionalization of Saturated Carbonyl Compounds-the State of the Art, ChemCatChem, 2014, 6(5): 1183~1185.

(5) Liang Wang，Dirk Menche，Concise synthesis of acetal-protected syn 1,3-diols by a tandem hemiacetal/ formation/Tsuji-Trost reaction, Angewandte Chemie International Edition, 2012, 51(37): 9425~9427

(6) Liang Wang，Dirk Mench，Construction of multisubstituted tetrahydropyrans by a domino oxa-Michael/Tsuji-Trost reaction，The Journal of Organic Chemistry, 2012, 77(23): 10811~10823

(7) Liang Wang, Pengfei Li, Dirk Menche, Concise synthesis of tetrahydropyrans by a tandem oxa-Michael/Tsuji-Trost reaction.，Angewandte Chemie International Edition, 2010, 49(48): 9270~9273

(8) Huaili Zhao，Mingyan Xiao，Lubin Xu，Liang Wang*， Jian Xiao，Bifunctional thiourea catalyzed asymmetric Michael addition of anthrone to methyleneindolinones，RSC Advances, 2016, 6(45): 38558~38562

(9) Huaili Zhao，Xiaoxiao Wang，Liang Wang*， Jian Xiao，Regioselective Michael Addition of Anthrone to Methyleneindolinones, Synthesis, 2016, 48(13): 2112~2120

(10) Jian Liu, Xiaoxiao Wang, Lubin Xu, Zhihui Hao, Liang Wang*, Jian Xiao *, One step synthesis of 2-alkenylchromanes via inverse-electron-demand Hetero-DielseAlder reaction of o-quinone methide with unactivated dienes, Tetrahedron 2016, 72, 7642-7649.

(11) Shuai Zhu, Chunqi Chen, Mingyan Xiao, Liping Yu, Liang Wang*, Jian Xiao*, Construction of the Tetrahydroquinoline Spiro Skeleton via Cascade [1,5]-Hydride Transfer-involved C(sp³)-H Functionalization “on Water”, Green Chem., 2017, 19(23): 5653.

(12) Chunqi Chen, Lubin Xu, Liang Wang* and Shuai-Shuai Li*, Efficient construction of tetrahydroquinolines via fluorinated alcohol mediated cascade [1,5]-hydride transfer/cyclization, Org. Biomol. Chem. 2018, 16, 7109–7114.

(13) Lubin Xu, Pengfei Yang and Liang Wang*, Direct functionalization of benzylic and nonbenzylic C(sp3)–H bonds via keteniminium ion initiated cascade [1,5]-hydrogen transfer/cyclization, Org. Chem. Front., 2018, 5, 1854–1858.

(14) Didi Ren, Lubin Xu, Liang Wang* and Shuai-Shuai Li*, Catalytic Formal Benzylic C-H Bond Functionalization of 2,5-Dialkylfuran Derivatives with Ferrocenyl Alcohols as Alkylation Reagents, Org. Lett. 2019, 21, 627.

(15) Shuai Zhu, Lubin Xu, Liang Wang*, Jian Xiao*, Recent Advances in Asymmetric Synthesis of Optically Active Indole Derivatives from 3-Indolylmethanols, Chin. J. Org. Chem. 2016, 36(6): 1229-1240.

(16) Mingyan Xiao，Shuai Zhu，Yaobin Shen，Liang Wang*, Jian Xiao*, Construction of Chiral Cyclic Compounds via Asymmetric Cascade [1,n]-Hydride Transfer/Cyclization, Chin. J. Org. Chem. 2018, 38(2): 328-340,

(17) Manli Yang, Liang Wang*, Yanzhi Xia*, Ammonium persulphate induced synthesis of polymethyl methacrylate grafted sodium alginate composite films with high strength for food packaging, Int. J. Bio. Macro. 2019, 124, 1238.

(18) Liang Wang, Jian Xiao, Hydrogen-Atom Transfer Reactions, Top. Curr. Chem. 2016, 374, 17.

(19) Xiaoxiao Wang, Jian Liu, Lubin Xu, Zhihui Hao, Liang Wang* and Jian Xiao*, Friedel–Crafts alkylation of heteroarenes and arenes with indolyl alcohols for construction of 3,3-disubstituted oxindoles, RSC Adv., 2015, 5, 101713–101717.

(20) Ye Liu, Yujian Mao, Yanwei Hu, Jingjing Gui, Liang Wang,* Wei Wang, Shilei Zhang*, The Employment of Sodium Hydride as a Michael Donor in Palladium-catalyzed Reductions of α, β-Unsaturated Carbonyl Compounds, Adv. Syn. Catal. 2019, DOI: 10.1002/adsc.201801676.

2. 非一作或通讯作者的文章

(1) Jian Liu，Liang Wang，Xiaoxiao Wang，Lubin Xu，Zhihui Hao，Jian Xiao, Fluorinated alcohol-mediated [4 + 3] cycloaddition reaction of indolyl alcohols with cyclopentadiene，Organic & Biomolecular Chemistry, 2016, 14(48): 11510~11517

(2) Shiheng Fu，Liang Wang，Haoxun Dong，Junqiang Yu，Lubin Xu，Jian Xiao，Facile synthesis of 2-alkenylazaarenes via dehydrative coupling of 2-methylazaarenes with aldehydes ‘on water’, Tetrahedron Letters, 2016, 57(41): 4533~4536

(3) Xianhui Zhang，Shuai-Shuai Li，Liang Wang，Lubin Xu，Jian Xiao，Zhen-Jiang Liu，2-Methylquinoline promoted oxidative ring-opening of N-sulfonyl aziridines with DMSO: facile synthesis of α-amino aryl ketones，Tetrahedron, 2016, 72(49): 8073~8077

(4) Haoxun Dong，Lubin Xu，Shuai-Shuai Li，Liang Wang，Chang-Lun Shao，Jian Xiao，Facile Synthesis of Azaarene-Substituted Hydroxycoumarins Possessing High Biological Activities via Three-Component C(sp(3))-H Functionalization, ACS Combinatorial Science, 2016, 18(9): 604~610

(5) Hao Wen，Liang Wang，Lubin Xu，Zhihui Hao，Chang-Lun Shao，Chang-Yun Wang，Jian Xiao，Fluorinated Alcohol-Mediated SN1-Type Reaction of Indolyl Alcohols with Diverse Nucleophiles，Advanced Synthesis & Catalysis, 2015，357(18): 4023~4030

(6) Jian Xiao，Hao Wen，Liang Wang，Lubin Xu，Zhihui Hao，Chang-Lun Shao，Chang-Yun Wang，Catalyst-free dehydrative S_N1-type reaction of indolyl alcohols with diverse nucleophiles “on water”, Green Chemistry, 2015, 18(4): 1032~1037

(7) Lubin Xu，Zhuzhou Shao，Liang Wang，Huaili Zhao，Jian Xiao，Catalyst-free synthesis of (E)-2-alkenylquinoline derivatives via C(sp3)-H functionalization of 2-methylquinolines，Tetrahedron Letters, 2014, 55(50):  6856~6860

(8) Zhuzhou Shao，Liang Wang，Lubin Xu，Huaili Zhao，Jian Xiao，Facile synthesis of azaarene-2-substituted chromanone derivatives via tandem sp3 C–H functionalization/decarboxylation of azaarenes with 4-oxo-4H-chromene-3-carboxylic acid，RSC Advances, 2014, 4(95): 53188~53191

(9) Jian Xiao, Yuye Chen, Shuai Zhu, Lubin Xu，Hongtao Wei, Liang Wang, Diversified Construction of Chromeno[3,4-c]pyridin-5-one and Benzo[c]chromen- 6-one Derivatives by Domino Reaction of 4-alkynyl-2-oxo-2H-chromene- 3-carbaldehydes，Advanced Synthesis & Catalysis, 2014, 356(8): 1835~1845

(10) Bin Tang，Liang Wang, Dirk Menche，Diastereoselective Synthesis of 1,3-syn-Oxazines via a Tandem Hemiaminalization/Tsuji-Trost Reaction, Synlett, 2013, 0(24): 625~629

(11) Lubin Xu, Zhuzhou Shao，Liang Wang，Jian Xiao，Tandem sp3 C-H functionlization/decarboxylation of 2-alkylazaarenes with coumarin-3-carboxylic acids.，Organic Letters, 2014, 16(3): 796~799

(12) Zhuzhou Shao，Lubin Xu，Liang Wang，Hongtao Wei，Jian Xiao，Catalyst-free tandem Michael addition/decarboxylation of (thio)coumarin-3- carboxylic acids with indoles: facile synthesis of indole-3-substituted 3,4-dihydro(thio)coumarins，Organic & Biomolecular Chemistry, 2014, 12(14): 2185~2188

(13) Zhuzhou Shao，Liang Wang，Lubin Xu，Huaili Zhao，Jian Xiao，Facile synthesis of azaarene-2-substituted chromanone derivatives via tandem sp3 C–H functionalization/decarboxylation of azaarenes with 4-oxo-4H-chromene-3- carboxylic acid，RSC Advances, 2014, 4(95): 53188~53191

(14) Shuai-Shuai Li, Lan Zhou, Liang Wang, Huaili Zhao, Liping Yu, and Jian Xiao, Organocatalytic C(sp3)−H Functionalization via Carbocation-Initiated Cascade [1,5]-Hydride Transfer/Cyclization: Synthesis of Dihydrodibenzo[b,e]-azepines, Organic Letters 2018, 20(1): 138−141

(15) Shuai-Shuai Li, Shiheng Fu, Liang Wang, Lubin Xu, and Jian Xiao, tBuOK-Mediated Oxidative Dehydrogenative C(sp3)H Arylation of 2Alkylazaarenes with Nitroarenes, The Journal of Organic Chemistry, 2017, 82(16): 8703−8709

(16) Xianhui Zhang, Shuai-Shuai Li, Liang Wang, Lubin Xu, Jian Xiao*, 2-Methylquinoline promoted oxidative ring-opening of N-sulfonyl aziridines with DMSO: facile synthesis of a-amino aryl ketones, Tetrahedron 2016, 72(49): 8073-8077.

(19) Shuai-Shuai Li, Lan Zhou, Liang Wang, Huaili Zhao, Liping Yu, and Jian Xiao*, Organocatalytic C(sp3)−H Functionalization via Carbocation-Initiated Cascade [1,5]-Hydride Transfer/Cyclization: Synthesis of Dihydrodibenzo- [b,e]azepines, Org. Lett. 2018, 20, 138−141.

(20) Wei Cao, Ping Chen, Liang Wang, Hao Wen, Yu Liu, Wanshu Wang and Yu Tang*, A Highly Regio- and Stereoselective Syntheses of αHalo Enamides, Vinyl Thioethers, and Vinyl Ethers with Aqueous Hydrogen Halide in Two-Phase Systems, Org. Lett. 2018, 20, 4507−4511.

(21) Yujian Mao,Ye Liu, Yanwei Hu, Liang Wang, Shilei Zhang* and Wei Wang*, Pd-Catalyzed Debenzylation and Deallylation of Ethers and Esters with Sodium Hydride, ACS Catal. 2018, 8, 3016−3020.

(22) Hao Wen, Wei Cao, Yu Liu, Liang Wang, Ping Chen,* and Yu Tang*, Metal-Free [2 + 2 + 2] Cycloaddition of Ynamide−Nitriles with Ynamides: A Highly Regio- and Chemoselective Synthesis of δCarboline Derivatives, J. Org. Chem. 2018, 83, 13308−13324.

(23) Yao-Bin Shen, Shuai-Shuai Li, Liang Wang, Xiao-De An, Qing Liu, Xicheng Liu, and Jian Xiao, Organocatalytic Dearomative [4 + 2] Cycloadditions of Biomass-Derived 2,5-Dimethylfuran with ortho-Quinone Methides: Access to Multisubstituted Chromanes, Org. Lett. 2018, 20, 6069−6073.